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AC 5216

Cat. No. 5281 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective TSPO ligand
别名： XBD173
化学名： N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AC 5216

AC 5216 is a ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.

化合物库 for AC 5216

AC 5216 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AC 5216

分子量 401.46
公式 C23H23N5O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 226954-04-7
PubChem ID 6433109
InChI Key NBMBIEOUVBHEBM-UHFFFAOYSA-N
Smiles O=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 5216

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.15 100

制备储备液 for AC 5216

以下数据基于产品分子量 401.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.45 mL 24.91 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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产品说明书 for AC 5216

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AC 5216

参考文献是支持产品生物活性的出版物。

Kita et al (2004) Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. Br.J.Pharmacol. 142 1059 PMID: 15249420

Qiu et al (2013) Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 45 40 PMID: 23624119

If you know of a relevant reference for AC 5216, please let us know.

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关键词: AC 5216, AC 5216 supplier, AC5216, anxiolytic, anti-anxiety, antidepressant, depression, mitochondrial, benzodiazepine, BZD, ligands, PBR, TSPO, GABAA, XBD173, Translocator, Protein, 5281, Tocris Bioscience

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