AC 55541

Cat. No. 3369 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective PAR₂ agonist

化学名： (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide

纯度： ≥97% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AC 55541

AC 55541 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

技术数据 for AC 55541

分子量	518.36
公式	C₂₅H₂₀BrN₅O₃
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	916170-19-9
PubChem ID	9589606
InChI Key	UCUHFWIFSHROPY-RWPZCVJISA-N
Smiles	O=C2C1=CC=CC=C1C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 55541

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	25.92	50

制备储备液 for AC 55541

以下数据基于产品分子量 518.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.86 mL	19.29 mL	38.58 mL
2.5 mM	0.77 mL	3.86 mL	7.72 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
25 mM	0.08 mL	0.39 mL	0.77 mL

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产品说明书 for AC 55541

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AC 55541

参考文献是支持产品生物活性的出版物。

Seitzberg et al (2008) Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 51 5490 PMID: 18720984

Gardell et al (2008) Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 327 799 PMID: 18768780

If you know of a relevant reference for AC 55541, please let us know.

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关键词: AC 55541, AC 55541 supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, AC55541, 3369, Tocris Bioscience