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Acetazolamide

Cat. No. 6742 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Carbonic anhydrase inhibitor
化学名： N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Acetazolamide

Acetazolamide is a carbonic anhydrase inhibitor. Modulates epileptiform synchronization in rat brain slices. Increases speed of synaptic vesicle recycling and changes synaptic performance in ex vivo murine neuromuscular junction. Lowers intracranial pressure in healthy rats. Also potentiates the antitumor effects of the HDAC inhibitor MS 275 (Cat. No. 6208).

化合物库 for Acetazolamide

Acetazolamide is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Acetazolamide

分子量 222.25
公式 C4H6N4O3S2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 59-66-5
PubChem ID 1986
InChI Key BZKPWHYZMXOIDC-UHFFFAOYSA-N
Smiles CC(NC1=NN=C(S(N)(=O)=O)S1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Acetazolamide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 22.23 100

制备储备液 for Acetazolamide

以下数据基于产品分子量 222.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.5 mL 44.99 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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参考文献 for Acetazolamide

参考文献是支持产品生物活性的出版物。

Bayat et al (2017) Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 17 156 PMID: 28235409

Uldall et al (2017) Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats. Neurosci.Lett. 645 33 PMID: 28219789

Bertone et al (2017) Carbonic anhydrase inhibitor acetazol. shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction. Synapse. 71 PMID: 28873252

Hamidi (2015) Carbonic anhydrase inhibition by acetazol. reduces in vitro epileptiform synchronization. Neuropharmacology. 95 377 PMID: 25937211

If you know of a relevant reference for Acetazolamide, please let us know.

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关键词: Acetazolamide, Acetazolamide supplier, Diamox, carbonic, anhydrase, inhibitors, inhibits, lowers, intracranial, pressure, Carbonic, anhydrases, 6742, Tocris Bioscience

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