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ACT 462206

Cat. No. 5319 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent, dual orexin receptor antagonist
化学名： (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ACT 462206

ACT 462206 is a potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

化合物库 for ACT 462206

ACT 462206 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ACT 462206

分子量 388.48
公式 C20H24N2O4S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1361321-96-1
PubChem ID 40924317
InChI Key NHPQGZOBHSVTAQ-IBGZPJMESA-N
Smiles CC1=CC(NC([C@@H]2CCCN2S(C3=CC=C(OC)C=C3)(=O)=O)=O)=CC(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ACT 462206

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.85 100
ethanol 38.85 100

制备储备液 for ACT 462206

以下数据基于产品分子量 388.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.74 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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参考文献 for ACT 462206

参考文献是支持产品生物活性的出版物。

Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486 PMID: 25147058

If you know of a relevant reference for ACT 462206, please let us know.

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关键词: ACT 462206, ACT 462206 supplier, ACT462206, Potent, dual, orexin, receptors, antagonists, OX1, OX2, DORA, anxiolytic, Non-selective, Orexin, 5319, Tocris Bioscience

1 篇 ACT 462206 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ACT 462206 的部分引用包括：

Abdel A et al (2021) Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension. Sci Rep 11 21050 PMID: 34702886

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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