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Submit ReviewACTH (1-39)
说明： Potent endogenous MC2 agonist
别名： Adrenocorticotropic hormone (1-39)
纯度： ≥95% (HPLC)
生物活性 for ACTH (1-39)
ACTH (1-39) is a potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.
技术数据 for ACTH (1-39)
| 分子量 | 4541.1 |
| 公式 | C207H308N56O58S |
| 序列 | SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 12279-41-3 |
| PubChem ID | 90488852 |
| InChI Key | KNOZNCXWNQVSDB-LAZPIJHFSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ACTH (1-39)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for ACTH (1-39)
参考文献 for ACTH (1-39)
参考文献是支持产品生物活性的出版物。
Kapas et al (1996) Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137 3291 PMID: 8754753
Iwen et al (2008) Melanocortin crosstalk with adipose functions: ACTH directly induces Ins resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes. J.Endocrinol. 196 465 PMID: 18310442
Bertolini et al (2009) Brain effects of melanocortins. Pharmacol.Res. 59 13 PMID: 18996199
If you know of a relevant reference for ACTH (1-39), please let us know.
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关键词: ACTH (1-39), ACTH (1-39) supplier, Potent, endogenous, MC2R, agonists, Receptors, Melanocortin, acethropan, Adrenocorticotropic, hormone, (1-39), 3492, Tocris Bioscience
4 篇 ACTH (1-39) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ACTH (1-39) 的部分引用包括：
Ewa et al (2021) Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Pain 162 432-445 PMID: 32826750
Martineau et al (2014) The atherogenic Scarb1 null mouse model shows a high bone mass phenotype. Am J Physiol Endocrinol Metab 306 E48 PMID: 24253048
Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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