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Submit ReviewAdapalene
说明： RARβ and RARγ agonist
别名： CD 271,Differin
化学名： 6-(4-Methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Adapalene
Adapalene is a retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.
化合物库 for Adapalene
Adapalene is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Adapalene
| 分子量 | 412.52 |
| 公式 | C28H28O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 106685-40-9 |
| PubChem ID | 60164 |
| InChI Key | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C3=CC=C(C=C(C(O)=O)C=C4)C4=C3)C=C1C25CC(C6)CC(CC6C5)C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Adapalene
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.31 | 25 |
制备储备液 for Adapalene
以下数据基于产品分子量 412.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.7 mL | 48.48 mL | 96.96 mL |
| 1.25 mM | 1.94 mL | 9.7 mL | 19.39 mL |
| 2.5 mM | 0.97 mL | 4.85 mL | 9.7 mL |
| 12.5 mM | 0.19 mL | 0.97 mL | 1.94 mL |
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产品说明书 for Adapalene
参考文献 for Adapalene
参考文献是支持产品生物活性的出版物。
Shroot et al (1997) Pharmacology and chemistry of adap. J.Am.Acad.Dermatol. 36 S96 PMID: 9204085
Millikan (2000) Adapalene: an update on newer comparative studies between the various retinoids. Int.J.Dermatol. 39 784 PMID: 11095202
Ocker et al (2003) The synthetic retinoid adap. inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Int.J.Cancer 107 453 PMID: 14506747
If you know of a relevant reference for Adapalene, please let us know.
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关键词: Adapalene, Adapalene supplier, RARβ, RARbeta, RARγ, RARgamma, agonists, Retinoic, Acid, Receptors, CD271, CD, 271, Differin, 2852, Tocris Bioscience
2 篇 Adapalene 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Adapalene 的部分引用包括：
Dhandapani et al (2011) Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression. Drug Des Devel Ther 71 5245 PMID: 21685476
Huk et al (2013) Increased dietary intake of vitamin A promotes aortic valve calcification in vivo. Arterioscler Thromb Vasc Biol 33 285 PMID: 23202364
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Adapalene 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.