Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewADX 10059 hydrochloride
说明： Negative allosteric modulator of mGlu5 receptors
别名： Raseglurant
化学名： 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for ADX 10059 hydrochloride
ADX 10059 hydrochloride is reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212).
化合物库 for ADX 10059 hydrochloride
ADX 10059 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ADX 10059 hydrochloride
| 分子量 | 276.74 |
| 公式 | C15H13FN2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 757949-98-7 |
| PubChem ID | 18454771 |
| InChI Key | BDXXMGYKLQZXOU-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=NC(C#CC2=CC=CC(F)=C2)=C1N.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ADX 10059 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 6.92 | 25 | |
| DMSO | 27.67 | 100 |
制备储备液 for ADX 10059 hydrochloride
以下数据基于产品分子量 276.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.61 mL | 18.07 mL | 36.14 mL |
| 5 mM | 0.72 mL | 3.61 mL | 7.23 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.61 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for ADX 10059 hydrochloride
参考文献 for ADX 10059 hydrochloride
参考文献是支持产品生物活性的出版物。
Weiss et al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891 PMID: 21757343
Keywood et al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192 PMID: 19460767
Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555 PMID: 20218930
If you know of a relevant reference for ADX 10059 hydrochloride, please let us know.
关键词: ADX 10059 hydrochloride, ADX 10059 hydrochloride supplier, metabotropics, glutamate, receptor, 5, mglur5, mglu5, NAMs, negative, allosteric, modulators, ADX10059, Raseglurant, Glutamate, (Metabotropic), Group, I, Receptors, 4416, Tocris Bioscience
篇 ADX 10059 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 ADX 10059 hydrochloride 的引用文献。 您是否知道使用了 Tocris ADX 10059 hydrochloride 的优秀论文？ 请告知我们.
ADX 10059 hydrochloride 的评论
目前没有该产品的评论。 Be the first to review ADX 10059 hydrochloride and earn rewards!
Have you used ADX 10059 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.