AEE 788

Name: AEE 788
Brand: Tocris Bioscience
SKU: 5318
Rating: 5 (2 reviews)

Cat. No. 5318 1 次引用 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent EGFR and VEGFR inhibitor

化学名： 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AEE 788

AEE 788 is a potent EGFR and VEGFR inhibitor (IC₅₀ values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC₅₀ values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

技术数据 for AEE 788

分子量	440.58
公式	C₂₇H₃₂N₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	497839-62-0
PubChem ID	10297043
InChI Key	OONFNUWBHFSNBT-HXUWFJFHSA-N
Smiles	C[C@@H](NC2=C(C=C(C4=CC=C(CN5CCN(CC)CC5)C=C4)N3)C3=NC=N2)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AEE 788

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	44.06	100

制备储备液 for AEE 788

以下数据基于产品分子量 440.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.7 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for AEE 788

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AEE 788

参考文献是支持产品生物活性的出版物。

Traxler et al (2004) AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 64 4931 PMID: 15256466

Yokoi et al (2005) Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. Cancer Res. 65 3716 PMID: 15867367

If you know of a relevant reference for AEE 788, please let us know.

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关键词: AEE 788, AEE 788 supplier, AEE788, potent, epidermal, vascular, endothelial, growth, factors, EGFR, VEGFR, ErbB2, antiangiogenic, antitumor, orally, active, 5318, Tocris Bioscience

1 篇 AEE 788 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AEE 788 的部分引用包括：

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Int J Mol Sci 6 9173 PMID: 25823819

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AEE 788 的评论

平均评分: 5 (基于 2 条评论。)

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Inhibits proliferation.

By Anonymous on 09/17/2022

分析类型： In Vitro

种属： Mouse

细胞系/组织： EGFR-hi cells

Used this to inhibit proliferation, looks great!

In vitro culture.

By Anonymous on 08/05/2018