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Submit ReviewAEG 3482
说明： Inhibitor of JNK signaling
化学名： 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
纯度： ≥99% (HPLC)
生物活性 for AEG 3482
AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
化合物库 for AEG 3482
AEG 3482 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for AEG 3482
| 分子量 | 280.33 |
| 公式 | C10H8N4O2S2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 63735-71-7 |
| PubChem ID | 698112 |
| InChI Key | MQUYTXDAVCOCMX-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C1=NN2C=C(N=C2S1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AEG 3482
参考文献 for AEG 3482
参考文献是支持产品生物活性的出版物。
Gallo (2006) Targeting HSP90 to halt neurodegeneration. Chem.Biol. 13 115 PMID: 16492558
Salehi et al (2006) AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem.Biol. 13 213 PMID: 16492569
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关键词: AEG 3482, AEG 3482 supplier, inhibitors, inhibits, JNK, signaling, Mitogen-Activated, Protein, Kinases, c-Jun, N-Terminal, SAPKs, Stress-Activated, AEG3482, JNK/c-jun, 2651, Tocris Bioscience
5 篇 AEG 3482 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AEG 3482 的部分引用包括：
Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693
Baston-Buest et al (2017) Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators Inflamm 2017 8379256 PMID: 28293067
Xiao et al (2019) Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov 5 2 PMID: 30622738
Roselli et al (2011) CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS One 6 e23097 PMID: 21829588
Lahiri et al (2016) ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability. Am J Cancer Res 6 910 PMID: 27293988
AEG 3482 的评论
平均评分: 3 (Based on 1 Review.)
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42 perturbagens used the zebrafish DASPEI screen.
By
Anonymous on 12/17/2019
分析类型： In Vivo
种属： Other
细胞系/组织： larvae
Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for AEG 3482
