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Submit ReviewAF 12198
说明： Potent, selective human type I IL-1 receptor antagonist
纯度： ≥95% (HPLC)
生物活性 for AF 12198
AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo.
技术数据 for AF 12198
| 分子量 | 1895.14 |
| 公式 | C96H123N19O22 |
| 序列 |
FEWTPGWYQXYALPL (Modifications: Phe-1 = N-terminal Ac, X = Aze, Leu-15 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 185413-30-3 |
| PubChem ID | 90488713 |
| InChI Key | VASLMBMCJADVGR-BRPRRQPRSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1CCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(C)=O)[C@@H](C)O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AF 12198
| 溶解性 | Soluble to 1 mg/ml in 10% ethanol/PBS |
产品说明书 for AF 12198
参考文献 for AF 12198
参考文献是支持产品生物活性的出版物。
Aimbire et al (2008) Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 31 189 PMID: 18421573
Akeson et al (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J.Biol.Chem. 271 30517 PMID: 8940020
If you know of a relevant reference for AF 12198, please let us know.
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关键词: AF 12198, AF 12198 supplier, Potent, selective, human, type, I, IL-1, receptors, antagonists, IL, Interleukins, Cytokines, AF12198, Cytokine, Receptors, 1793, Tocris Bioscience
1 篇 AF 12198 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AF 12198 的部分引用包括：
Lin et al (2010) Interleukin-1β expression is required for lysophosphatidic Acid-induced lymphangiogenesis in human umbilical vein endothelial cells. J Psychopharmacol 2011 351010 PMID: 21151531
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AF 12198 的评论
平均评分: 5 (Based on 1 Review.)
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ICD-related studies.
By
MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human
The antagonist for the human type I interleukin-1 (IL-1) receptor was used in studies exploring immunogenic cell death induced by chemotherapeutics. Results were consistent.