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Submit ReviewAG 18
说明： EGFR/PDGFR-kinase inhibitor
别名： RG-50810,Tyrphostin A23
化学名： [(3,4-Dihydroxyphenyl)methylene]-propenedinitrile
生物活性 for AG 18
AG 18 is an inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
技术数据 for AG 18
| 分子量 | 186.17 |
| 公式 | C10H6N2O2 |
| 储存 | Desiccate at +4°C |
| CAS Number | 118409-57-7 |
| PubChem ID | 2052 |
| InChI Key | VTJXFTPMFYAJJU-UHFFFAOYSA-N |
| Smiles | OC1=C(O)C=C(\C=C(/C#N)C#N)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 18
参考文献 for AG 18
参考文献是支持产品生物活性的出版物。
Gazit et al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933 PMID: 3263702
Gazit et al (1989) Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J.Biol.Chem. 264 14503 PMID: 2788167
Gazit et al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782 PMID: 7892601
Soltoff (2004) Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J.Biol.Chem. 279 10910 PMID: 14688271
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关键词: AG 18, AG 18 supplier, EGFR, PDGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, Platelet, Derived, AG18, RG50810, RG-50810, Tyrphostin, A23, 0493, Tocris Bioscience
1 篇 AG 18 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AG 18 的部分引用包括：
Villalba et al (2007) Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries. Am J Physiol Heart Circ Physiol 292 H1157 PMID: 17085536
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.