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说明： Potent EGFR-kinase inhibitor
化学名： (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
生物活性 for AG 494
AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively).
技术数据 for AG 494
| 分子量 | 280.28 |
| 公式 | C16H12N2O3 |
| 储存 | Desiccate at +4°C |
| CAS Number | 133550-35-3 |
| PubChem ID | 5328771 |
| InChI Key | HKHOVJYOELRGMV-XYOKQWHBSA-N |
| Smiles | OC1=C(O)C=C(\C=C(/C#N)C(=O)NC2=CC=CC=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 494
参考文献 for AG 494
参考文献是支持产品生物活性的出版物。
Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442 PMID: 10454524
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
Tomlins et al (2005) Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp.Cell Res. 308 439 PMID: 15950968
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关键词: AG 494, AG 494 supplier, Potent, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, AG494, 0619, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.