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Submit ReviewAG 556
说明： EGFR-kinase inhibitor
别名： Tyrphostin AG 556
化学名： (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
纯度： ≥99% (HPLC)
生物活性 for AG 556
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM). Selective over ErbB2 (IC50 > 500 μM).
技术数据 for AG 556
| 分子量 | 336.39 |
| 公式 | C20H20N2O3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 133550-41-1 |
| PubChem ID | 5328775 |
| InChI Key | GWCNJMUSWLTSCW-SFQUDFHCSA-N |
| Smiles | OC1=C(O)C=C(\C=C(/C#N)C(=O)NCCCCC2=CC=CC=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 556
参考文献 for AG 556
参考文献是支持产品生物活性的出版物。
Gamett et al (1997) Secondary dimerization between members of the epidermal growth factor receptor family. J.Biol.Chem. 272 12052 PMID: 9115272
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428
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关键词: AG 556, AG 556 supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, AG556, Tyrphostin, AG, 556, 0616, Tocris Bioscience
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