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Submit ReviewAG 825
说明： Selective ErbB2 inhibitor
别名： Tyrphostin AG 825
化学名： 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
生物活性 for AG 825
AG 825 is a selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
技术数据 for AG 825
| 分子量 | 397.47 |
| 公式 | C19H15N3O3S2 |
| 储存 | Store at +4°C |
| CAS Number | 149092-50-2 |
| PubChem ID | 6091659 |
| InChI Key | KXDONFLNGBQLTN-WUXMJOGZSA-N |
| Smiles | COC1=CC(\C=C(/C#N)C(N)=O)=CC(CSC2=NC3=C(S2)C=CC=C3)=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 825
参考文献 for AG 825
参考文献是支持产品生物活性的出版物。
Gazit et al (1993) Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J.Med.Chem. 36 3556 PMID: 7902440
Murillo et al (2001) Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21. Cancer Res. 61 7408 PMID: 11606371
Osherov et al (1993) Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins. J.Biol.Chem. 268 11134 PMID: 8098709
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关键词: AG 825, AG 825 supplier, Selective, ErbB2, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, AG825, Tyrphostin, AG, 825, 1555, Tocris Bioscience
5 篇 AG 825 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AG 825 的部分引用包括：
Wu et al (2016) Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem 136 250 PMID: 26438054
Lee et al (2014) Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation. Cancer Res 74 341 PMID: 24177178
Lucchetti et al (2013) The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer. PLoS One 8 e55355 PMID: 23390529
Akhtar et al (2013) Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS One 8 e67813 PMID: 23826343
Kedrin et al (2009) ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clin Cancer Res 15 3733 PMID: 19458057
AG 825 的评论
平均评分: 5 (Based on 1 Review.)
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In vitro culture.
By
Anonymous on 08/05/2018
分析类型： In Vitro
种属： Mouse
Used in vitro to investigate ERG pathways
该领域的文献
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