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AG 825

Cat. No. 1555 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective ErbB2 inhibitor
别名： Tyrphostin AG 825
化学名： 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
说明书
引用文献 (5)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AG 825

AG 825 is a selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

技术数据 for AG 825

分子量 397.47
公式 C19H15N3O3S2
储存 Store at +4°C
CAS Number 149092-50-2
PubChem ID 6091659
InChI Key KXDONFLNGBQLTN-WUXMJOGZSA-N
Smiles COC1=CC(\C=C(/C#N)C(N)=O)=CC(CSC2=NC3=C(S2)C=CC=C3)=C1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AG 825

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.75 100

制备储备液 for AG 825

以下数据基于产品分子量 397.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for AG 825

参考文献是支持产品生物活性的出版物。

Gazit et al (1993) Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J.Med.Chem. 36 3556 PMID: 7902440

Murillo et al (2001) Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21. Cancer Res. 61 7408 PMID: 11606371

Osherov et al (1993) Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins. J.Biol.Chem. 268 11134 PMID: 8098709

If you know of a relevant reference for AG 825, please let us know.

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关键词: AG 825, AG 825 supplier, Selective, ErbB2, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, AG825, Tyrphostin, AG, 825, 1555, Tocris Bioscience

5 篇 AG 825 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AG 825 的部分引用包括：

Lucchetti et al (2013) The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer. PLoS One 8 e55355 PMID: 23390529

Akhtar et al (2013) Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction. PLoS One 8 e67813 PMID: 23826343

Kedrin et al (2009) ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clin Cancer Res 15 3733 PMID: 19458057

Wu et al (2016) Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem 136 250 PMID: 26438054

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AG 825 的评论

平均评分: 5 (Based on 1 Review.)

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In vitro culture.
By Anonymous on 08/05/2018
分析类型： In Vitro
种属： Mouse

Used in vitro to investigate ERG pathways

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