Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAG 879
说明： TrkA inhibitor
别名： Tyrphostin AG 879
化学名： (2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide
纯度： ≥99% (HPLC)
生物活性 for AG 879
AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. Decreases cellular proliferation in human muscular sarcoma cell lines. Also inhibits ErbB2 and VEGFR-2 (IC50 values are approximately 1 μM for both).
技术数据 for AG 879
| 分子量 | 316.46 |
| 公式 | C18H24N2OS |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 148741-30-4 |
| PubChem ID | 5487525 |
| InChI Key | LCUMYVYIHXYBIA-FOWTUZBSSA-N |
| Smiles | CC(C)(C)C1=CC(/C=C(C#N)/C(N)=S)=CC(C(C)(C)C)=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 879
参考文献 for AG 879
参考文献是支持产品生物活性的出版物。
He et al (2004) The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol.Ther. 3 96 PMID: 14726663
Rende et al (2006) Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. Anticancer Drugs 17 929 PMID: 16940803
按产品操作查看相关产品
关键词: AG 879, AG 879 supplier, AG879, tyrosine, kinase, inhibitors, ErbB2, VEGFR-2, EGFR, Flk-1, nerve, growth, factors, inhibits, NGF, TrkA, Tyrphostin, AG, 879, Trk, Receptors, VEGFR, 2617, Tocris Bioscience
1 篇 AG 879 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AG 879 的部分引用包括：
Ledonne et al (2015) Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry 20 959 PMID: 25266126
AG 879 的评论
目前没有该产品的评论。 Be the first to review AG 879 and earn rewards!
Have you used AG 879?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.