Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAG 99
说明： EGFR-kinase inhibitor
化学名： (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
纯度： ≥99% (HPLC)
生物活性 for AG 99
AG 99 is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro.
技术数据 for AG 99
| 分子量 | 204.18 |
| 公式 | C10H8N2O3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 122520-85-8 |
| PubChem ID | 5328768 |
| InChI Key | USOXQZNJFMKTKJ-XVNBXDOJSA-N |
| Smiles | NC(=O)C(=C\C1=CC(O)=C(O)C=C1)\C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AG 99
参考文献 for AG 99
参考文献是支持产品生物活性的出版物。
Gazit et al (1989) Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344 PMID: 2552117
Gazit (1996) Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J.Med.Chem. 39 4905 PMID: 8960549
Levitzki and Gilon (1991) Tyrphostins as molecular tools and potential antiproliferative drugs. TiPS 12 171 PMID: 1862529
Yamamoto et al (2006) Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J.Cell Sci. 119 4623 PMID: 17062641
按产品操作查看相关产品
关键词: AG 99, AG 99 supplier, EGFR, kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, AG99, 0497, Tocris Bioscience
AG 99 的评论
目前没有该产品的评论。 Be the first to review AG 99 and earn rewards!
Have you used AG 99?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.