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Agitoxin 2

Cat. No. 5195 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5195 has been discontinued.

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说明： Potent Shaker K+ channel blocker
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Agitoxin 2

Agitoxin 2 is a potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).

技术数据 for Agitoxin 2

分子量 4090.87
公式 C169H278N54O48S8
序列 GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK

(Modifications: Disulfide bridge: 8-28,14-33,18-35)

储存 Store at -20°C
CAS Number 168147-41-9
PubChem ID 90489022
InChI Key MNSSWZUIQUJZTG-UHFFFAOYSA-N
Smiles [H]NCC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Agitoxin 2

参考文献是支持产品生物活性的出版物。

Garcia et al (1994) Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry 33 6834 PMID: 8204618

Anangi et al (2012) Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers. PLoS ONE 7 e52965 PMID: 23300835

Gross et al (1996) Agitoxin footprinting the shaker potassium channel pore. Neuron 16 399 PMID: 8789954

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关键词: Agitoxin 2, Agitoxin 2 supplier, potent, shaker, potassium, K+, channels, blockers, inhibits, inhibitors, Kv1.4, kv1.1, kv1.3, kv1.6, voltage, gated, venoms, Voltage-Gated, Potassium, Channels, 5195, Tocris Bioscience

篇 Agitoxin 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Agitoxin 2 的评论

平均评分: 5 (Based on 1 Review.)

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Agitoxin 2 was used on Kv1.3 channels.
By Anonymous on 02/12/2019
种属： Human

Agitoxin 2 was used on Kv1.3 channels. The percentage blocking against increasing concentration of Agitoxin 2 was measured.

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