AGN 192403 hydrochloride

Cat. No. 1072 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： I₁ selective ligand

别名： BRD4780

化学名： (±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AGN 192403 hydrochloride

AGN 192403 hydrochloride is an i₁ imidazoline binding site selective ligand with a potency at I₁ comparable to moxonidine, but devoid of affinity for adrenoceptors and the I₂ binding site. Causes none of the physiological responses associated with the I₁ binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

技术数据 for AGN 192403 hydrochloride

分子量	189.73
公式	C₁₀H₁₉N.HCl
储存	Store at RT
CAS Number	1021868-90-5
PubChem ID	11957452
InChI Key	KSTGYMXUFHCTSM-UHFFFAOYSA-N
Smiles	Cl.CC(C)C1C(C2CC1CC2)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AGN 192403 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		100

制备储备液 for AGN 192403 hydrochloride

以下数据基于产品分子量 189.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	5.27 mL	26.35 mL	52.71 mL
5 mM	1.05 mL	5.27 mL	10.54 mL
10 mM	0.53 mL	2.64 mL	5.27 mL
50 mM	0.11 mL	0.53 mL	1.05 mL

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产品说明书 for AGN 192403 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AGN 192403 hydrochloride

参考文献是支持产品生物活性的出版物。

Mukaddam-Daher et al (2006) Receptors involved in moxonidine-stimulated strial natriuretic peptide released from isolated normotensive rat hearts. Eur.J.Pharmacol. 541 73 PMID: 16774751

Munk et al (1996) Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline₁ receptor specific agent. J.Med.Chem. 39 1193 PMID: 8632424

Raasch et al (2002) Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br.J.Pharmacol. 135 663 PMID: 11834614

Dvela-Levitt (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885

If you know of a relevant reference for AGN 192403 hydrochloride, please let us know.

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关键词: AGN 192403 hydrochloride, AGN 192403 hydrochloride supplier, I1, selective, ligands, Imidazoline, Receptors, AGN192403, hydrochloride, mutant, MUC1, mucin-1, TMED9, proteinopathy, BRD4780, Other, ER, stress/UPR, 1072, Tocris Bioscience

2 篇 AGN 192403 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AGN 192403 hydrochloride 的部分引用包括：

Dvela-Levitt et al (2019) Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy. Cell 178 521 PMID: 31348885

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010

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