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AKOS 022

Cat. No. 7135 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Voltage-dependent anion channel (VDAC) inhibitor
化学名： 1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AKOS 022

AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.

化合物库 for AKOS 022

AKOS 022 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AKOS 022

分子量 467.87
公式 C22H21ClF3N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 878983-38-1
PubChem ID 5304523
InChI Key ZZVCWIMICOFQNJ-UHFFFAOYSA-N
Smiles FC(F)(OC1=CC=C(C=C1)NC2CCN(C3CC(N(C4=CC=C(C=C4)Cl)C3=O)=O)CC2)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AKOS 022

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.79 100

制备储备液 for AKOS 022

以下数据基于产品分子量 467.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.69 mL 21.37 mL
5 mM 0.43 mL 2.14 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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参考文献 for AKOS 022

参考文献是支持产品生物活性的出版物。

Ben-Hail et al (2016) Novel compounds targeting the mitochondrial protein VDAC1 inhibit apoptosis and protect against mitochondrial dysfunction. J.Biol.Chem. 291 24986 PMID: 27738100

Zhang et al (2019) Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells. Cell Metab. 29 64 PMID: 30293774

If you know of a relevant reference for AKOS 022, please let us know.

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关键词: AKOS 022, AKOS 022 supplier, AKOS022, AKOS022075291, AKOS, 022075291, voltage-dependent, anion, channel, VDAC, inhibitors, inhibits, anti-apoptotic, Other, Channel, Modulators, 7135, Tocris Bioscience

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