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Submit Review[Ala17]-MCH
Discontinued Product
3434 has been discontinued.
View all Melanin-concentrating Hormone Receptors products.
说明： Potent MCH receptor agonist
生物活性 for [Ala17]-MCH
[Ala17]-MCH is a potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
技术数据 for [Ala17]-MCH
| 分子量 | 2271.71 |
| 公式 | C97H155N29O26S4 |
| 序列 |
DFDMLRCMLGRVYRPCAQV (Modifications: Disulfide bridge between 7 - 16) |
| 储存 | Store at -20°C |
| CAS Number | 359784-84-2 |
| PubChem ID | 90488845 |
| InChI Key | IVEALEKXBDDRGB-UKPWUPKZSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for [Ala17]-MCH
参考文献 for [Ala17]-MCH
参考文献是支持产品生物活性的出版物。
Bednarek et al (2001) Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. Biochemistry 40 9379 PMID: 11478907
Gao et al (2004) Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal.Biochem. 328 187 PMID: 15113696
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关键词: [Ala17]-MCH, [Ala17]-MCH supplier, Potent, MCH, receptors, agonists, Melanin-concentrating, Hormone, MCH1, MCH2, MCH2R, MCHR2, MCH1R, MCHR1, Receptors, 3434, Tocris Bioscience
1 篇 [Ala17]-MCH 的引用文献
引用文献是使用了 Tocris 产品的出版物。 [Ala17]-MCH 的部分引用包括：
Camp et al (2016) Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol Res 105 13 PMID: 26773201
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