主页 / 药理学 / Enzymes / Dehydrogenases / Aldehyde Dehydrogenases / Aldehyde Dehydrogenase Activators / Alda 1

Alda 1

Cat. No. 4005 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： ALDH2 activator; cardioprotective
化学名： N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Alda 1

Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.

化合物库 for Alda 1

Alda 1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Alda 1

分子量 324.16
公式 C15H11Cl2NO3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 349438-38-6
PubChem ID 831629
InChI Key NMKJFZCBCIUYHI-UHFFFAOYSA-N
Smiles O=C(C3=C(Cl)C=CC=C3Cl)NCC1=CC(OCO2)=C2C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Alda 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.42 100
ethanol 3.24 10

制备储备液 for Alda 1

以下数据基于产品分子量 324.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.42 mL 30.85 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Alda 1

参考文献是支持产品生物活性的出版物。

Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493 PMID: 18787169

Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitrogly. and effects of alda-1. J.Biol.Chem. 285 943 PMID: 19906643

If you know of a relevant reference for Alda 1, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Aldehyde Dehydrogenase Activators

关键词: Alda 1, Alda 1 supplier, aldehyde, dehydrogenases, activators, aldh2, aldh2*1, aldh2*2, aldh22, aldh21, cardiac, ischemia, Alda1, Aldehyde, Dehydrogenase, 4005, Tocris Bioscience

2 篇 Alda 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Alda 1 的部分引用包括：

Tao et al (2020) Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study. BMC Ophthalmol 20 55 PMID: 32070320

Ling et al (2021) Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. Alcohol Clin Exp Res 45 1950-1964 PMID: 34486131

您是否知道使用了 Tocris Alda 1 的优秀论文？ 请告知我们.

Alda 1 的评论

目前没有该产品的评论。 Be the first to review Alda 1 and earn rewards!

Have you used Alda 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review