主页 / 药理学 / Enzyme-Linked Receptors / Integrins / Integrin Ligands / Alkyne-cRGD

Alkyne-cRGD

Cat. No. 8042 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Integrin ligand for degrader development and targeted delivery, with alkyne click handle for conjugation
纯度： ≥95% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Alkyne-cRGD

Alkyne-cRGD is an integrin ligand for degrader development and targeted delivery. It contains an alkyne handle that enables the attachment of additional groups via copper-catalyzed azide-alkyne cycloaddition click reactions.

技术数据 for Alkyne-cRGD

分子量 713.78
公式 C33H47N9O9
序列 RGDYK

(Modifications: Tyr-4 = D-Tyr, Lys-5 = N6-(1-oxo-5-hexyn-1-yl)-Lys, Lactam bridge: Arg-1 to Lys-5)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2665674-77-9
InChI Key HWGZAFMOVGJTMT-JBXUNAHCSA-N
Smiles NC(NCCC[C@H](NC([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)N2)=O)CCCCNC(CCCC#C)=O)=O)C(NCC(N[C@@H](CC(O)=O)C2=O)=O)=O)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Alkyne-cRGD

溶解性 Soluble to 2 mg/ml in water

参考文献 for Alkyne-cRGD

参考文献是支持产品生物活性的出版物。

Zheng et al (2022) Bifunctional compounds as molecular degraders for integrin-facilitated targeted protein degradation. J.Am.Chem.Soc. 144 21831 PMID: 36417563

If you know of a relevant reference for Alkyne-cRGD, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Integrin Ligands

关键词: Alkyne-cRGD, Alkyne-cRGD supplier, click-activated, ligands, targeted, degraders, protein, degradation, development, copper-catalyzed, azide-alkyne, cycloaddition, Integrins, Biochemicals, and, Molecular, Biology, LYTAC, Building, Blocks, 8042, Tocris Bioscience

篇 Alkyne-cRGD 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Alkyne-cRGD 的引用文献。 您是否知道使用了 Tocris Alkyne-cRGD 的优秀论文？ 请告知我们.

Alkyne-cRGD 的评论

目前没有该产品的评论。 Be the first to review Alkyne-cRGD and earn rewards!

Have you used Alkyne-cRGD?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.