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Submit ReviewAltanserin hydrochloride
说明： 5-HT2A receptor antagonist
化学名： 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Altanserin hydrochloride
Altanserin hydrochloride is a potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo.
化合物库 for Altanserin hydrochloride
Altanserin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Altanserin hydrochloride
| 分子量 | 447.95 |
| 公式 | C22H22FN3O2S.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1135280-78-2 |
| PubChem ID | 24978536 |
| InChI Key | JFPPLMAMMZZOEA-UHFFFAOYSA-N |
| Smiles | Cl.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=S)NC3=CC=CC=C3C2=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Altanserin hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 8.96 | 20 温和加热 |
制备储备液 for Altanserin hydrochloride
以下数据基于产品分子量 447.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.16 mL | 55.81 mL | 111.62 mL |
| 1 mM | 2.23 mL | 11.16 mL | 22.32 mL |
| 2 mM | 1.12 mL | 5.58 mL | 11.16 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
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产品说明书 for Altanserin hydrochloride
参考文献 for Altanserin hydrochloride
参考文献是支持产品生物活性的出版物。
Herth et al (2009) Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg.Med.Chem. 17 2989 PMID: 19329329
Kennett et al (1994) Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114 90 PMID: 7846211
Koenig et al (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 137 1 PMID: 2956114
Sietnick (1985) Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 61 65 PMID: 3872342
If you know of a relevant reference for Altanserin hydrochloride, please let us know.
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关键词: Altanserin hydrochloride, Altanserin hydrochloride supplier, 5-HT2A, receptor, antagonists, Serotonin, Receptors, 1809, Tocris Bioscience
2 篇 Altanserin hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Altanserin hydrochloride 的部分引用包括：
Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. Am J Physiol Regul Integr Comp Physiol 6 e21395 PMID: 21789169
Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol 102 752 PMID: 19474172
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.