ALX 5407 hydrochloride

Cat. No. 1757 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective non-transportable GlyT1 inhibitor

别名： (+)-NFPS

化学名： N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ALX 5407 hydrochloride

ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC₅₀ values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC₅₀ > 100 μM).

Racemate also available.

许可信息

Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only

化合物库 for ALX 5407 hydrochloride

ALX 5407 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ALX 5407 hydrochloride

分子量	429.92
公式	C₂₄H₂₄FNO₃.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	200006-08-2
PubChem ID	16078946
InChI Key	RPDGSZCYSJWQEE-GNAFDRTKSA-N
Smiles	FC(C=C2)=CC=C2[C@@H](CCN(CC(O)=O)C)OC1=CC=C(C3=CC=CC=C3)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ALX 5407 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	21.5	50
	DMSO	42.99	100

制备储备液 for ALX 5407 hydrochloride

以下数据基于产品分子量 429.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.63 mL	23.26 mL
5 mM	0.47 mL	2.33 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for ALX 5407 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ALX 5407 hydrochloride

参考文献是支持产品生物活性的出版物。

Atkinson et al (2001) ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 60 1414 PMID: 11723250

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151

If you know of a relevant reference for ALX 5407 hydrochloride, please let us know.

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1 篇 ALX 5407 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ALX 5407 hydrochloride 的部分引用包括：

Yue et al (2016) Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nat.Commun. 7 13501 PMID: 27874011

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