AM 0902

Cat. No. 5914 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective TRPA1 antagonist

化学名： 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AM 0902

AM 0902 is a potent and selective TRPA1 antagonist (IC₅₀ = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.

化合物库 for AM 0902

AM 0902 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AM 0902

分子量	370.79
公式	C₁₇H₁₅ClN₆O₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1883711-97-4
PubChem ID	73297271
InChI Key	AWJBWNUUODWOKQ-UHFFFAOYSA-N
Smiles	CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AM 0902

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	37.08	100

制备储备液 for AM 0902

以下数据基于产品分子量 370.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.7 mL	13.48 mL	26.97 mL
5 mM	0.54 mL	2.7 mL	5.39 mL
10 mM	0.27 mL	1.35 mL	2.7 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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产品说明书 for AM 0902

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AM 0902

参考文献是支持产品生物活性的出版物。

Schenkel et al (2016) Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 59 2794 PMID: 26942860

If you know of a relevant reference for AM 0902, please let us know.

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关键词: AM 0902, AM 0902 supplier, AM0902, analgesic, potent, selective, transient, receptor, potential, A1, TRPA1, antagonists, antagonism, orally, bioavailable, 5914, Tocris Bioscience