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Submit ReviewAM 404 (in Tocrisolve™ 100)
说明： Anandamide transport inhibitor (in water-soluble emulsion)
化学名： N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
生物活性 for AM 404 (in Tocrisolve™ 100)
Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM), in water-soluble emulsion (for details see TocrisolveTM 100 Cat. No. 1684). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available as solid AM 404 (Cat. No. 1116).
技术数据 for AM 404 (in Tocrisolve™ 100)
| 分子量 | 395.58 |
| 公式 | C26H37NO2 |
| 储存 | Store at +4°C |
| CAS Number | 198022-70-7 |
| PubChem ID | 6604822 |
| Smiles | O=C(NC1=CC=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM 404 (in Tocrisolve™ 100)
参考文献 for AM 404 (in Tocrisolve™ 100)
参考文献是支持产品生物活性的出版物。
Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094 PMID: 9262477
Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1 PMID: 9389389
Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802 PMID: 10318965
Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39 PMID: 10822052
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关键词: AM 404 (in Tocrisolve 100), AM 404 (in Tocrisolve 100) supplier, Vanilloid, receptor, agonists, anandamide, transporters, inhibitors, inhibits, water-soluble, emulsion, Anandamide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, AMT, cannabinoids, Monoamine, Neurotransmitter, AM404, Cannabinoid, Transporters, 1685, Tocris Bioscience
2 篇 AM 404 (in Tocrisolve™ 100) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AM 404 (in Tocrisolve™ 100) 的部分引用包括：
Costa et al (2014) 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction 147 301 PMID: 24324206
Tan et al (2011) Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex. J Neurosci 31 5300 PMID: 21471365
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