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Submit ReviewAM 80
说明： RARα agonist; anticancer agent
别名： Tamibarotene
化学名： 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for AM 80
AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.
化合物库 for AM 80
AM 80 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AM 80
| 分子量 | 351.44 |
| 公式 | C22H25NO3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 94497-51-5 |
| PubChem ID | 108143 |
| InChI Key | MUTNCGKQJGXKEM-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AM 80
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 17.57 | 50 | |
| ethanol | 17.57 | 50 |
制备储备液 for AM 80
以下数据基于产品分子量 351.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.69 mL | 28.45 mL | 56.91 mL |
| 2.5 mM | 1.14 mL | 5.69 mL | 11.38 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 25 mM | 0.11 mL | 0.57 mL | 1.14 mL |
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产品说明书 for AM 80
参考文献 for AM 80
参考文献是支持产品生物活性的出版物。
Kagechika et al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182 PMID: 3184125
Jimi et al (2007) RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 31 397 PMID: 17611697
Takenaga et al (2009) The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 32 225 PMID: 19182380
Kasamoto et al (2023) Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart. Stem Cell Reports S2213-6711 00235-7 PMID: 37451261
If you know of a relevant reference for AM 80, please let us know.
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关键词: AM 80, AM 80 supplier, RARα, RARalpha, agonists, anticancer, Retinoic, Acid, Receptors, AM80, cardiomyocytes, cell, cycle, activators, activation, Tamibarotene, Cardiomyocyte, Stem, Cells, 3507, Tocris Bioscience
2 篇 AM 80 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AM 80 的部分引用包括：
Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191
Mickaël M et al (2020) A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Rep 30 914-931.e9 PMID: 31968263
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.