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Ambrisentan

Cat. No. 5828 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective ETA antagonist
化学名： (αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ambrisentan

Ambrisentan is a selective endothelin receptor ETA antagonist. Displays approximately 200-fold selectivity for ETA over ETB (Ki values are 1 nM and 195 nM for respectively). Prevents endothelin-induced sudden death in rats.

化合物库 for Ambrisentan

Ambrisentan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ambrisentan

分子量 378.42
公式 C22H22N2O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 177036-94-1
PubChem ID 6918493
InChI Key OUJTZYPIHDYQMC-LJQANCHMSA-N
Smiles CC1=CC(C)=NC(O[C@H](C(O)=O)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ambrisentan

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.84 100
ethanol 37.84 100

制备储备液 for Ambrisentan

以下数据基于产品分子量 378.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Ambrisentan

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ambrisentan

参考文献是支持产品生物活性的出版物。

Riechers et al (1996) Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J.Med.Chem. 39 2123 PMID: 8667356

Vatter & Seifert (2006) Ambrisentan, a non-peptide endothelin receptor antagonist. Cardiovasc.Drug Rev. 24 63 PMID: 16939634

If you know of a relevant reference for Ambrisentan, please let us know.

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关键词: Ambrisentan, Ambrisentan supplier, endothelin, ETA, receptor, antagonists, inhibits, antagonism, selective, Endothelin, Receptors, 5828, Tocris Bioscience

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