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AMD 3465 hexahydrobromide

Cat. No. 4179 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective CXCR4 antagonist
化学名： N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
纯度： ≥97% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AMD 3465 hexahydrobromide

AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

化合物库 for AMD 3465 hexahydrobromide

AMD 3465 hexahydrobromide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AMD 3465 hexahydrobromide

分子量 896.07
公式 C24H38N6.6HBr
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 185991-07-5
PubChem ID 9897616
InChI Key ARHBIBDGWDRBJH-UHFFFAOYSA-N
Smiles C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMD 3465 hexahydrobromide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 44.8 50
DMSO 22.4 25

制备储备液 for AMD 3465 hexahydrobromide

以下数据基于产品分子量 896.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.23 mL 11.16 mL 22.32 mL
2.5 mM 0.45 mL 2.23 mL 4.46 mL
5 mM 0.22 mL 1.12 mL 2.23 mL
25 mM 0.04 mL 0.22 mL 0.45 mL

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产品说明书 for AMD 3465 hexahydrobromide

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for AMD 3465 hexahydrobromide

参考文献是支持产品生物活性的出版物。

Rosenkilde et al (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 282 27354 PMID: 17599916

Bodart et al (2009) Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 78 993 PMID: 19540208

If you know of a relevant reference for AMD 3465 hexahydrobromide, please let us know.

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关键词: AMD 3465 hexahydrobromide, AMD 3465 hexahydrobromide supplier, AMD3465, CXCR4, receptor, antagonist, chemokine, chemokines, antagonists, Chemokine, CXC, Receptors, 4179, Tocris Bioscience

3 篇 AMD 3465 hexahydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AMD 3465 hexahydrobromide 的部分引用包括：

Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213

Luo et al (2016) Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain. Mol Pain 12 PMID: 27030717

David L et al (2015) Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea. Invest Ophthalmol Vis Sci 56 7250-9 PMID: 26544793

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AMD 3465 hexahydrobromide 的评论

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Used for Migration assays.
By Anonymous on 07/01/2020
分析类型： In Vitro
种属： Human
细胞系/组织： A549 or MDAMB231

Receptor antagonists (SB225002: for CXCR2, AMD3465: for CXCR4, RS504393: for CCR2 and Maraviroc: for CCR5) at 10 μM

We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists

PMID: 25712213
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