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AMG 21629

Cat. No. 4330 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective TRPV1 antagonist
化学名： 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AMG 21629

AMG 21629 is a potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors (IC50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

技术数据 for AMG 21629

分子量 472.42
公式 C22H19F3N6O3
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 939040-79-6
PubChem ID 24858024
InChI Key TUMYQRZCVIQKOQ-UHFFFAOYSA-N
Smiles NC(C(N4)=O)=NC(C4=CC=C3)=C3OC1=CC(C2=CC=C(C(F)(F)F)C=C2)=NC(NCCOC)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG 21629

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.62 50

制备储备液 for AMG 21629

以下数据基于产品分子量 472.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.23 mL 21.17 mL 42.34 mL
2.5 mM 0.85 mL 4.23 mL 8.47 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
25 mM 0.08 mL 0.42 mL 0.85 mL

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参考文献 for AMG 21629

参考文献是支持产品生物活性的出版物。

Tamayo et al (2008) Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists. J.Med.Chem. 51 2744 PMID: 18386885

Gavva et al (2007) The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J.Neurosci. 27 3366 PMID: 17392452

If you know of a relevant reference for AMG 21629, please let us know.

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关键词: AMG 21629, AMG 21629 supplier, AMG21629, transient, receptor, potential, vanilloid, TRPV1, antagonists, antagonism, orally, available, potent, selective, hyperthermia, TRPV, 4330, Tocris Bioscience

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