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AMG 853

Cat. No. 5701 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
化学名： 5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneacetic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AMG 853

AMG 853 is a potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.

技术数据 for AMG 853

分子量 609.49
公式 C28H27Cl2FN2O6S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1169483-24-2
PubChem ID 42641863
InChI Key PFWVGKROPKKEDW-UHFFFAOYSA-N
Smiles ClC1=CC(C2CC2)=CC=C1S(NC3=CC(C(NC(C)(C)C)=O)=CC=C3OC4=C(Cl)C=C(CC(O)=O)C(F)=C4)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG 853

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 60.95 100
ethanol 60.95 100

制备储备液 for AMG 853

以下数据基于产品分子量 609.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.2 mL 16.41 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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参考文献 for AMG 853

参考文献是支持产品生物活性的出版物。

Liu et al (2011) Discovery of AMG 853, a CRTH2 and DP dual antagonist. ACS Med.Chem.Lett. 2 326 PMID: 24900313

If you know of a relevant reference for AMG 853, please let us know.

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关键词: AMG 853, AMG 853 supplier, AMG853, CRTH2, chemoattractant, receptor-homologous, molecule, expressed, on, Th2, cells, PGD2, prostaglandin, receptor, dual, antagonists, antagonism, orally, DP2, bioavailable, Prostanoid, Receptors, 5701, Tocris Bioscience

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AMG 853 blocks p38 phosphorylation in 15d-PGJ2 treated cardiomyocytes.
By Chintan Koyani on 12/10/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： HL-1 cardiomyocytes

HL-1 cardiomyocytes were pre-incubated with AMG 853 (1 µM, 30 min) followed by treatment with 15d-PGJ2 (15 µM, 30 min) to follow p38 activation using Western blot analysis. AMG 853 inhibited 15d-induced p38 phosphorylation.

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