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Submit ReviewAMI-193
说明： D2-like antagonist; also selective 5-HT2 antagonist
别名： Spiramide
化学名： 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone
纯度： ≥99% (HPLC)
生物活性 for AMI-193
AMI-193 is a selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.
技术数据 for AMI-193
| 分子量 | 383.46 |
| 公式 | C22H26FN3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 510-74-7 |
| PubChem ID | 68186 |
| InChI Key | FJUKDAZEABGEIH-UHFFFAOYSA-N |
| Smiles | FC(C=C4)=CC=C4OCCCN1CCC2(N(C3=CC=CC=C3)CNC2=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AMI-193
参考文献 for AMI-193
参考文献是支持产品生物活性的出版物。
Czoty et al (2000) Behavioural effects of AMI-193, a 5-HT2A- and DA D2-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67 257 PMID: 11124389
Ismaiel et al (1993) Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist. J.Med.Chem. 36 2519 PMID: 8355253
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关键词: AMI-193, AMI-193 supplier, Selective, 5-HT2, antagonists, D2-like, receptor, Non-Selective, Serotonin, Receptors, Dopamine, dopaminergic, spiramide, Spiramide, Non-selective, 0524, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.