Aminopurvalanol A

Cat. No. 2072 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

别名： NG 97

化学名： (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Aminopurvalanol A

Aminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC₅₀ = 12.0 μM) and ERK2 (IC₅₀ = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC₅₀ >100 μM). Arrests cell cycle at G2/M boundary (IC₅₀ = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

许可信息

Sold under license from the Regents of the University of California

化合物库 for Aminopurvalanol A

Aminopurvalanol A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Aminopurvalanol A

分子量	403.91
公式	C₁₉H₂₆ClN₇O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	220792-57-4
PubChem ID	6604931
InChI Key	RAMROQQYRRQPDL-HNNXBMFYSA-N
Smiles	ClC1=CC(N)=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Aminopurvalanol A

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.39	100

制备储备液 for Aminopurvalanol A

以下数据基于产品分子量 403.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.38 mL	24.76 mL
5 mM	0.5 mL	2.48 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for Aminopurvalanol A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Aminopurvalanol A

参考文献是支持产品生物活性的出版物。

Chang et al (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 6 361 PMID: 10375538

Knockaert et al (2000) Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 7 411 PMID: 10873834

Rosiana et al (1999) A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA 96 4797

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for Aminopurvalanol A, please let us know.

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关键词: Aminopurvalanol A, Aminopurvalanol A supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, AminopurvalanolA, NG97, NG, 97, Kinase, Non-selective, CDKs, 2072, Tocris Bioscience

1 篇 Aminopurvalanol A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Aminopurvalanol A 的部分引用包括：

Teo et al (2006) An evolutionary conserved role of Wnt signaling in stem cell fate decision. Dev Biol 289 91 PMID: 16309665

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