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说明： Selective D2 and D3 antagonist; atypical antipsychotic
别名： DAN 2163
化学名： 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
纯度： ≥98% (HPLC)
生物活性 for Amisulpride
Amisulpride is a potent, selective dopamine D2 and D3 receptor antagonist. Ki values are 2.8 and 3.2 nM respectively for human D2 and D3 and > 1000 nM for human D1, D4 and D5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2/D3 receptors at higher doses. Preferentially interacts with limbic D2-like receptors in vivo. Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
技术数据 for Amisulpride
| 分子量 | 369.48 |
| 公式 | C17H27N3O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 71675-85-9 |
| PubChem ID | 2159 |
| InChI Key | NTJOBXMMWNYJFB-UHFFFAOYSA-N |
| Smiles | CCN1CCCC1CNC(=O)C1=C(OC)C=C(N)C(=C1)S(=O)(=O)CC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Amisulpride
参考文献 for Amisulpride
参考文献是支持产品生物活性的出版物。
Perrault et al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 DA receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73 PMID: 8996184
Schoemaker et al (1997) Neurochemical characteristics of amisulpride, an atypical DA D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 280 83 PMID: 8996185
Moller (2003) Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat. 27 1101
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关键词: Amisulpride, Amisulpride supplier, Selective, D2/D3, receptor, antagonists, atypical, antipsychotic, agent, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, DAN2163, DAN, 2163, Non-selective, 2132, Tocris Bioscience
2 篇 Amisulpride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Amisulpride 的部分引用包括：
Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518
Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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