Amlodipine besylate

Name: Amlodipine besylate
Brand: Tocris Bioscience
SKU: 2571
Rating: 5 (1 reviews)

Cat. No. 2571 2 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Ca_V1.x blocker

别名： Norvasc

化学名： 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Amlodipine besylate

Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

化合物库 for Amlodipine besylate

Amlodipine besylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Amlodipine besylate

分子量	567.05
公式	C₂₀H₂₅ClN₂O₅.C₆H₆O₃S
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	111470-99-6
PubChem ID	60496
InChI Key	ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Smiles	OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Amlodipine besylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	56.7	100

制备储备液 for Amlodipine besylate

以下数据基于产品分子量 567.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.82 mL	17.64 mL
5 mM	0.35 mL	1.76 mL	3.53 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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产品说明书 for Amlodipine besylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Amlodipine besylate

参考文献是支持产品生物活性的出版物。

Burges et al (1987) Calcium channel blocking properties of amlod. in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 9 110 PMID: 2434785

Yoshida et al (2003) Antiproliferative effect of Ca²⁺ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 472 23 PMID: 12860469

Toba et al (2005) Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hype Hypertens.Res. 28 689 PMID: 16392774

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关键词: Amlodipine besylate, Amlodipine besylate supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Norvasc, Cav1.x, 2571, Tocris Bioscience

2 篇 Amlodipine besylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Amlodipine besylate 的部分引用包括：

Sharma et al (2016) Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection PLoS One 11 e0163845 PMID: 27723836

Zhong et al (2014) Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva). PLoS One 9 e104718 PMID: 25121483

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