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Amyloid β-Peptide (12-28) (human) is an amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo.
分子量 | 1955.2 |
公式 | C89H135N25O25 |
序列 | VHHQKLVFFAEDVGSNK |
储存 | Desiccate at -20°C |
CAS Number | 107015-83-8 |
PubChem ID | 24868224 |
InChI Key | WOMPQPMHRDDZMP-IJBWYZRXSA-N |
Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Flood et al (1994) An amyloid β-protein fragment, A b[12-28], equipotent impairs post-training memory processing when injected into different limbic system structures. Brain Res. 663 271 PMID: 7874511
Freir and Herron (2003) Nicotine enhances the depressive actions of A β 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo. J.Neurophysiol. 89 2917 PMID: 12611941
Ray et al (1998) Binding of amyloid b-protein to intracellular brain proteins in rat and human. Neurochem.Res. 23 1277 PMID: 9804283
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