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CD22L-N3 (BPC-Sia-LacNAc-N3)

Cat. No. 8830 Submit a Review Datasheet / COA / SDS
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Description: CD22L ligand with azide group for onward chemistry
Chemical Name: (2R,4S,5R,6R)-6-((1R,2R)-3-([1,1'-Biphenyl]-4-carboxamido)-1,2-dihydroxypropyl)-5-acetamido-2-(((2R,3R,4S,5R,6S)-6-(((2R,3S,4R,5R,6R)-5-acetamido-6-(2-azidoethoxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methoxy)-4-hydroxytetrahydro-2H-pyran-2-carboxylic acid
Purity: ≥95% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CD22L-N3 (BPC-Sia-LacNAc-N3)

CD22L-N3 (BPC-Sia-LacNAc-N3) is a functionalized CD22 receptor ligand for trogocytosis targeting chimera (TrogoTAC) research and development. CD22 targeted TrogoTACs are bispecific molecules capable of inducing protein transfer from the target cell to B cells, by redirecting trogocytosis. Comprises an azide functionalized CD22 ligand for conjugation.

Technical Data for CD22L-N3 (BPC-Sia-LacNAc-N3)

M. Wt 922.89
Formula C40H54N6O19
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1019642-47-7
PubChem ID 101550018
InChI Key UTCPJMHBEGWJPH-LPKWDFCZSA-N
Smiles O(C[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@H](OCCN=[N+]=[N-])[C@H](NC(C)=O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O)[C@@]3(C(O)=O)O[C@@]([C@@H]([C@@H](CNC(=O)C4=CC=C(C=C4)C5=CC=CC=C5)O)O)([C@H](NC(C)=O)[C@@H](O)C3)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CD22L-N3 (BPC-Sia-LacNAc-N3)

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 92.29 100
water 92.29 100

Preparing Stock Solutions for CD22L-N3 (BPC-Sia-LacNAc-N3)

The following data is based on the product molecular weight 922.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.08 mL 5.42 mL 10.84 mL
5 mM 0.22 mL 1.08 mL 2.17 mL
10 mM 0.11 mL 0.54 mL 1.08 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets for CD22L-N3 (BPC-Sia-LacNAc-N3)

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for CD22L-N3 (BPC-Sia-LacNAc-N3)

References are publications that support the biological activity of the product.

Till et al (2024) Trogocytosis targeting chimeras (TrogoTACs) for targeted protein transfer. ChemRxiv

If you know of a relevant reference for CD22L-N3 (BPC-Sia-LacNAc-N3), please let us know.

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Citations for CD22L-N3 (BPC-Sia-LacNAc-N3)

Citations are publications that use Tocris products.

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