Anagrelide hydrochloride

Name: Anagrelide hydrochloride
Brand: Tocris Bioscience
SKU: 2432

Cat. No. 2432 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2432 has been discontinued.

View all Phosphodiesterases products.

说明： Potent PDE3 inhibitor

别名： BL 4162A

化学名： 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Anagrelide hydrochloride

Anagrelide hydrochloride is a potent type III phosphodiesterase (PDE3) inhibitor (IC₅₀ = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

技术数据 for Anagrelide hydrochloride

分子量	292.55
公式	C₁₀H₇Cl₂N₃O.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	58579-51-4
PubChem ID	42786
InChI Key	TVWRQCIPWUCNMI-UHFFFAOYSA-N
Smiles	ClC1=C(CN(C3)C(N2)=NC3=O)C2=CC=C1Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Anagrelide hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Anagrelide hydrochloride

参考文献是支持产品生物活性的出版物。

Gillespie (1988) Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity. Biochem.Pharmacol. 37 2866 PMID: 2456068

Mazur et al (1992) Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. Blood 79 1931 PMID: 1562721

Wang et al (2005) Comparison of the biological activities of anagr. and its major metabolites in haematopoietic cell cultures. Br.J.Pharmacol. 146 324 PMID: 16041400

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关键词: Anagrelide hydrochloride, Anagrelide hydrochloride supplier, Potent, PDE3, inhibitors, inhibits, Phosphodiesterases, BL4162A, BL, 4162A, 2432, Tocris Bioscience

篇 Anagrelide hydrochloride 的引用文献

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目前没有 Anagrelide hydrochloride 的引用文献。