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Anastrozole

Cat. No. 3388 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3388 has been discontinued.

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说明： Potent aromatase (CYP19) inhibitor
别名： ZD1033
化学名： α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Anastrozole

Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.

许可信息

Sold for research purposes only under agreement from AstraZeneca

化合物库 for Anastrozole

Anastrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Anastrozole

分子量 293.37
公式 C17H19N5
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 120511-73-1
PubChem ID 2187
InChI Key YBBLVLTVTVSKRW-UHFFFAOYSA-N
Smiles CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Anastrozole

参考文献是支持产品生物活性的出版物。

Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439 PMID: 8903429

Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697 PMID: 9394367

Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6 PMID: 11900212

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