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Submit ReviewANR 94
说明： Adenosine A2A antagonist
化学名： 8-Ethoxy-9-ethyl-9H-purin-6-amine
纯度： ≥99% (HPLC)
生物活性 for ANR 94
ANR 94 is an adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.
化合物库 for ANR 94
ANR 94 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ANR 94
| 分子量 | 207.23 |
| 公式 | C9H13N5O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 634924-89-3 |
| PubChem ID | 11805896 |
| InChI Key | QUGDTMONBLMLLD-UHFFFAOYSA-N |
| Smiles | CCN2C1=NC=NC(N)=C1N=C2OCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ANR 94
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.36 | 50 | |
| ethanol | 20.72 | 100 |
制备储备液 for ANR 94
以下数据基于产品分子量 207.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
| 10 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.97 mL |
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产品说明书 for ANR 94
参考文献 for ANR 94
参考文献是支持产品生物活性的出版物。
Pinna et al (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58 613 PMID: 19951715
Volpini et al (2010) Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 4 1010 PMID: 19343763
If you know of a relevant reference for ANR 94, please let us know.
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关键词: ANR 94, ANR 94 supplier, ANR94, adenosine, A2A, receptor, antagonist, AA2AR, antagonists, antiparkinsonian, activity, Adenosine, Receptors, 3937, Tocris Bioscience
1 篇 ANR 94 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ANR 94 的部分引用包括：
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Circulation 14 201 PMID: 26597723
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.