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Antagonist G

Cat. No. 1954 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Broad spectrum neuropeptide receptor antagonist
别名： [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Antagonist G

Antagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.

技术数据 for Antagonist G

分子量 951.2
公式 C49H66N12O6S
序列 RWFWLM

(Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide)
储存 Desiccate at -20°C
CAS Number 115150-59-9
PubChem ID 163960
InChI Key CUCSSYAUKKIDJV-FAXBSAIASA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Antagonist G

参考文献是支持产品生物活性的出版物。

Woll and Rozengurt (1990) A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 50 3968 PMID: 1693879

Langdon et al (1992) Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res. 52 4554 PMID: 1379515

MacKinnon et al (2000) [Arg6, D-Trp7,9, NmePhe8]-Substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy. Br.J.Cancer 83 941 PMID: 10970698

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关键词: Antagonist G, Antagonist G supplier, Broad, spectrum, neuropeptide, receptors, antagonists, Tachykinin, Non-Selective, Neurokinin, AntagonistG, neuropeptides, [Arg6,D-Trp7,9,N-MePhe8]-Substance, P(6-11), Other, Peptide, Receptors, 1954, Tocris Bioscience

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