Tachykinin Receptors
The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.
Literature for Tachykinin Receptors
Tocris offers the following scientific literature for Tachykinin Receptors to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Tachykinin Receptor Data
| Receptor Subtype | NK1 | NK2 | NK3 |
|---|---|---|---|
| Transduction Mechanism | Activates Gq/11 | Activates Gq/11 | Activates Gq/11 |
| Localization | CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei), peripheral tissues | Periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle), limited expression in the CNS | CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord), limited expression in the periphery |
| Preferred Endogenous Ligand | Substance P (1156) > Neurokinin A (1152) > Neurokinin B (1582) | Neurokinin A (1152) > Neurokinin B (1582) > Substance P (1156) | Neurokinin B (1582) > Neurokinin A (1152) > Substance P (1156) |
| Selective Agonists |
GR 73632 (1669) Hemokinin-1 (mouse) (1535) [Sar9,Met(O2)11]-Substance P (1178) Hemokinin-1 (human) (2576) |
GR 64349 (1668) [bAla8]-Neurokinin A(4-10) (1640) [Lys5,MeLeu9,Nle10]-NKA(4-10) (3228) |
Senktide (1068) |
| Selective Antagonists |
FK 888 (2400) GR 82334 (1670) L-732,138 (0868) L-733,060 (1145) RP 67580 (1635) SDZ NKT 343 (2394) |
GR 159897 (1274) MDL 29,913 (1194) MEN 10376 (1632) MEN 10627 |
SB 218795 (1376) SB 222200 (1393) |
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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