AP 14145 hydrochloride

Cat. No. 6481 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Negative allosteric modulator of K_Ca2 (SK) channels

化学名： N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AP 14145 hydrochloride

AP 14145 hydrochloride is a K_Ca2 (small conductance Ca²⁺-activated potassium) channel negative allosteric modulator (IC₅₀ = 1.1 μM). Increases the EC₅₀ of Ca²⁺ on K_Ca2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

技术数据 for AP 14145 hydrochloride

分子量	398.81
公式	C₁₈H₁₇F₃N₄O.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2387505-59-9
InChI Key	KGIUXIYNTCVBST-HNCPQSOCSA-N
Smiles	C[C@H](C1=CC(C(F)(F)F)=CC=C1)NC2=NC3=CC=CC(NC(C)=O)=C3N2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AP 14145 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	39.88	100
	ethanol	39.88	100

制备储备液 for AP 14145 hydrochloride

以下数据基于产品分子量 398.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.54 mL	25.07 mL
5 mM	0.5 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for AP 14145 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AP 14145 hydrochloride

参考文献是支持产品生物活性的出版物。

Diness et al (2017) Termination of vernakalant-resistant atrial fibrillation by inhibition of small-conductance Ca²⁺-activated K⁺ channels in pigs. Circ.Arrhythm.Electrophysiol. 10 e005125 PMID: 29018164

Simó-Vicens et al (2017) A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K_Ca2) channels. Br.J.Pharmacol. 174 4396 PMID: 28925012

If you know of a relevant reference for AP 14145 hydrochloride, please let us know.

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