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AP 18

Cat. No. 3296 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Reversible TRPA1 channel blocker
化学名： 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AP 18

AP 18 is a reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnamaldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).

化合物库 for AP 18

AP 18 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AP 18

分子量 209.67
公式 C11H12ClNO
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 55224-94-7
PubChem ID 9584673
InChI Key MHTJEUOFLVQMCL-NJHPPEEMSA-N
Smiles ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AP 18

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.97 100
ethanol 20.97 100

制备储备液 for AP 18

以下数据基于产品分子量 209.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.77 mL 23.85 mL 47.69 mL
5 mM 0.95 mL 4.77 mL 9.54 mL
10 mM 0.48 mL 2.38 mL 4.77 mL
50 mM 0.1 mL 0.48 mL 0.95 mL

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产品说明书 for AP 18

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AP 18

参考文献是支持产品生物活性的出版物。

Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40 PMID: 18086313

Chen et al (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol.Pain 5 3 PMID: 19159452

Taylor-Clark et al (2009) Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol.Pharmacol. 75 820 PMID: 19171673

If you know of a relevant reference for AP 18, please let us know.

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关键词: AP 18, AP 18 supplier, Reversible, TRPA1, channel, blockers, Channels, Transient, Receptor, Potential, AP18, 3296, Tocris Bioscience

2 篇 AP 18 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AP 18 的部分引用包括：

Capasso et al (2012) Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol 165 1966 PMID: 21955242

Izzo et al (2012) Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol 166 1444 PMID: 22300105

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