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Submit ReviewAP 811
说明： High affinity, selective NPR3 antagonist
纯度： ≥95% (HPLC)
生物活性 for AP 811
AP 811 is a high affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.
技术数据 for AP 811
| 分子量 | 915.1 |
| 公式 | C46H66N12O8 |
| 序列 |
RIDR (Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 124833-45-0 |
| PubChem ID | 44301714 |
| InChI Key | UNMJSSQZDQBGDS-OCFLPWLCSA-N |
| Smiles | CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AP 811
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for AP 811
参考文献 for AP 811
参考文献是支持产品生物活性的出版物。
Veale et al (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 10 1949 PMID: 10987424
William et al (2008) Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 294 C1067 PMID: 18272821
Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335 PMID: 24353062
If you know of a relevant reference for AP 811, please let us know.
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关键词: AP 811, AP 811 supplier, AP811, NPR3, ANP-CR, atrial, natriuretic, peptides, clearance, receptor, antagonists, antagonism, selective, high, affinity, Natriuretic, Peptide, Receptor, 5498, Tocris Bioscience
2 篇 AP 811 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AP 811 的部分引用包括：
Wei et al (2021) Atrial Natriuretic Peptide Promotes Neurite Outgrowth and Survival of Cochlear Spiral Ganglion Neurons in vitro Through NPR-A/cGMP/PKG Signaling. Front Cell Dev Biol 9 681421 PMID: 34268307
Zhen et al (2021) C-Type Natriuretic Peptide Ameliorates Vascular Injury and Improves Neurological Outcomes in Neonatal Hypoxic-Ischemic Brain Injury in Mice. Int J Mol Sci 22 PMID: 34445671
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AP 811 的评论
平均评分: 4 (Based on 1 Review.)
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Good NPR3 agonist.
By
Anonymous on 07/12/2018
分析类型： Ex Vivo
种属： Rat
Investigation of NPR3 agonism in blood vessels.
AP811 is extremely unstable. Shipped at RT as powder, but need to be frozen upon arrival and made fresh each time.