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APY 29

Cat. No. 4865 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
化学名： N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for APY 29

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.

化合物库 for APY 29

APY 29 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for APY 29

分子量 332.36
公式 C17H16N8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1216665-49-4
PubChem ID 42627755
InChI Key WJNBSTLIALIIEW-UHFFFAOYSA-N
Smiles C1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=CC(C5CC5)=NN4)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for APY 29

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.24 100
1eq. HCl 16.62 50

制备储备液 for APY 29

以下数据基于产品分子量 332.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for APY 29

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for APY 29

参考文献是支持产品生物活性的出版物。

Wang et al (2012) Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 8 982 PMID: 23086298

Korennykh et al (2009) The unfolded protein response signals through high-order assembly of Ire1. Nature 457 687 PMID: 19079236

If you know of a relevant reference for APY 29, please let us know.

按标靶查看相关产品

关键词: APY 29, APY 29 supplier, APY29, inhibits, IRE1a, IRE1alpha, IRE1α, endoribonuclease, RNase, activates, autophosphorylation, auto, phosphorylation, esterases, inhibitors, activators, ER-stress, IRE1, 4865, Tocris Bioscience

2 篇 APY 29 的引用文献

引用文献是使用了 Tocris 产品的出版物。 APY 29 的部分引用包括：

Ju-Ri et al (2020) IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv 6 eaax9914 PMID: 32128399

Govindarajan et al (2018) Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun 9 5340 PMID: 30559399

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