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AR-C 141990 hydrochloride

Cat. No. 5658 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MCT1 inhibitor
化学名： 5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AR-C 141990 hydrochloride

AR-C 141990 hydrochloride is a monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.

技术数据 for AR-C 141990 hydrochloride

分子量 529.05
公式 C26H28N4O4S.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2250019-94-2
PubChem ID 129316183
InChI Key NFFGLQDNUHBVEY-UNTBIKODSA-N
Smiles O=C(N1C[C@H](O)CC1)C2=C(CC3=C4C(C=CC=C4)=NC=C3)SC(N5CC(C)C)=C2C(N(C)C5=O)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AR-C 141990 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 49.26 100
DMSO 49.26 100

制备储备液 for AR-C 141990 hydrochloride

以下数据基于产品分子量 529.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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产品说明书 for AR-C 141990 hydrochloride

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参考文献 for AR-C 141990 hydrochloride

参考文献是支持产品生物活性的出版物。

Påhlman et al (2012) Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 26 22 PMID: 23137339

Thiesen et al (2015) In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 354 166 PMID: 25986445

If you know of a relevant reference for AR-C 141990 hydrochloride, please let us know.

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关键词: AR-C 141990 hydrochloride, AR-C 141990 hydrochloride supplier, AR-C141990, HCl, monocarboxylate, transporter, 1, MCT1, immunosuppressant, graft, versus, host, GvH, transplant, Monocarboxylate, Transporters, 5658, Tocris Bioscience

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