AR-C 66096 tetrasodium salt

Name: AR-C 66096 tetrasodium salt
Brand: Tocris Bioscience
SKU: 3321

Cat. No. 3321 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3321 has been discontinued.

View all Purinergic (P2Y) Receptors products.

说明： Potent and selective P2Y₁₂ antagonist

别名： FPL 66096,ARL 66096

化学名： 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt

纯度： ≥98% (HPLC)

说明书

引用文献 (7)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for AR-C 66096 tetrasodium salt

AR-C 66096 tetrasodium salt is a potent and selective P2Y₁₂ receptor antagonist. Blocks ADP-induced inhibition of adenylyl cyclase in vitro (pK_B =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC₅₀ = 8.16).

许可信息

Sold for research purposes under agreement from AstraZeneca

技术数据 for AR-C 66096 tetrasodium salt

分子量	703.26
公式	C₁₄H₁₈F₂N₅Na₄O₁₂P₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	145782-74-7
PubChem ID	90488830
InChI Key	IETVOLFQZIGNAQ-HVYRMSERSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].CCCSC1=NC(N)=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)C(F)(F)P([O-])([O-])=O)[C@@H](O)[C@H]3O)C2=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for AR-C 66096 tetrasodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AR-C 66096 tetrasodium salt

参考文献是支持产品生物活性的出版物。

Humphries et al (1994) FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br.J.Pharmacol. 113 1057 PMID: 7858849

Ingall et al (1999) Antagonists of the platelet P receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213 PMID: 9925726

Simon et al (2001) Activity of adenosine diphosphates and triphosphates on a P2YT-type receptor in brain capillary endothelial cells. Br.J.Pharmacol. 132 173 PMID: 11156575

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Purinergic (P2Y) Receptors

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7 篇 AR-C 66096 tetrasodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AR-C 66096 tetrasodium salt 的部分引用包括：

Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal 509 119 PMID: 24784220

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Cell Commun Signal 9 31 PMID: 22825617

Helms et al (2013) Mechanisms of hemolysis-associated platelet activation. J Thromb Haemost 11 2148 PMID: 24119131

Pinheiro et al (2013) Bradykinin-induced Ca²⁺ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499

Aungraheeta et al (2016) Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood 128 2717 PMID: 27694321

Lu et al (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9 242 PMID: 29725296

Chan et al (2018) Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Platelets 29 686 PMID: 29715047