AR-C 69931 tetrasodium salt

Cat. No. 5720 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent P2Y₁₂ antagonist

别名： Cangrelor tetrasodium salt

化学名： N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt

纯度： ≥98% (HPLC)

引用文献 (6)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AR-C 69931 tetrasodium salt

AR-C 69931 tetrasodium salt is a highly potent P2Y₁₂ antagonist (IC₅₀ = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.

技术数据 for AR-C 69931 tetrasodium salt

分子量	864.29
公式	C₁₇H₂₁Cl₂F₃N₅Na₄O₁₂P₃S₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	163706-36-3
PubChem ID	10260031
InChI Key	COWWROCHWNGJHQ-OPKBHZIBSA-J
Smiles	O[C@@H]1[C@H](O)[C@@H](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[C@H]1COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AR-C 69931 tetrasodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	86.43	100

制备储备液 for AR-C 69931 tetrasodium salt

以下数据基于产品分子量 864.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.16 mL	5.79 mL	11.57 mL
5 mM	0.23 mL	1.16 mL	2.31 mL
10 mM	0.12 mL	0.58 mL	1.16 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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产品说明书 for AR-C 69931 tetrasodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AR-C 69931 tetrasodium salt

参考文献是支持产品生物活性的出版物。

Huang et al (2000) Prevention of arterial thrombosis by intravenously administered platelet P_2T receptor antagonist AR-C69931MX in a canine model. J.Pharmacol.Exp.Ther. 295 492 PMID: 11046080

Ingall et al (1999) Antagonists of the platelet P_2T receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 42 213 PMID: 9925726

Srinivasan et al (2009) The P2Y₁₂ antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a G_i-independent increase in cAMP levels. J.Biol.Chem. 284 16108 PMID: 19346255

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Purinergic (P2Y) Receptors

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6 篇 AR-C 69931 tetrasodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AR-C 69931 tetrasodium salt 的部分引用包括：

Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386

Vivek et al (2020) Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. Elife 9 PMID: 32667883

Yu et al (2020) Cancer associated fibroblast FAK regulates malignant cell metabolism. Nat Commun 11 1290 PMID: 32157087

Lu et al (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol 9 242 PMID: 29725296

Sally et al (2019) Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci 39 7840-7852 PMID: 31451581

H C et al (2000) Activation of group II metabotropic glutamate receptors induces long-term depression of synaptic transmission in the rat amygdala. J Neurosci 20 9017-24 PMID: 11124977

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