AR-M 1896

Name: AR-M 1896
Brand: Tocris Bioscience
SKU: 2699

Cat. No. 2699 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2699 has been discontinued.

View all Galanin Receptors products.

说明： GAL₂ agonist

别名： Gal(2-11)amide

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for AR-M 1896

Selective galanin GAL₂ receptor agonist (IC₅₀ values are 1.76 and 879 nM for GAL₂ and GAL₁ respectively). Also shows moderate affinity for GAL₃ receptors (K_i values are 88 and 271 nM for GAL₂ and GAL₃ respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability.

技术数据 for AR-M 1896

分子量	1136.31
公式	C₅₄H₈₁N₁₃O₁₄
序列	WTLNSAGYLL (Modifications: Leu-10 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	367518-31-8
PubChem ID	6324638
InChI Key	SUJPPMXJCZETOA-ZKEPBWIVSA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for AR-M 1896

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AR-M 1896

参考文献是支持产品生物活性的出版物。

Lu et al (2005) Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 39 165 PMID: 15944007

Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066

Liu et al (2001) Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc.Natl.Acad.Sci USA 98 9960

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关键词: AR-M 1896, AR-M 1896 supplier, Selective, GAL2, GalR2, agonists, Receptors, Galanin, ARM1896, Gal(2-11)amide, 2699, Tocris Bioscience

1 篇 AR-M 1896 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AR-M 1896 的部分引用包括：

Li et al (2017) Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosis in the Ischemic Mouse Brain via GalR1. Aging Dis 8 85 PMID: 28203483

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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.